4-Amino-1-tert-butyl-3-(1’-naphthyl)pyrazolo[3,4-d]pyrimidine

A potent and uniquely specific tyrosine kinase inhibitor of an engineered v-Src tyrosine kinase. A selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl which preferentially inhibits mutant over wild-type knases. 

References
[1] Bishop, A.C., et al.: J. Am. Chem. Soc., 121, 627 (1999) [2] Davies, S., et al.: Biochem. J., 351, 95 (2000) [3] Regan, J., et al.: J. Med. Chem., 45, 2994 (2002) [4] Bain, J., et al.: Biochem. J., 371, 199 (2003) [5] Kuma, Y., et al.: J. Biol. Chem., 280, 19472 (2005)