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Darunavir

Product Code

TRC-D193500-5MG

CAS Number

206361-99-1

Product Format

Neat

Matrix

-

Molecular Formula

C27 H37 N3 O7 S

Molecular Weight

547.66

Pack Size:

5 mg

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Product Information

Darunavir is a second generation HIV-1 and HCV protease inhibitor; structurally similar to amprenavir. It is an antiviral that has a high genetic barrier to resistance. Across a diverse population of HIV-1-infected subjects treated with darunavir 800 mg QD regimens, the development of darunavir resistance was rare (<0.1%). 

 

References

[1] Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003).

[2] Arasteh, K., et al.: AIDS, 19, 943 (2005).

[3] Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005) [4] Lathouwers, E., Wong, E., Luo, D., Seyedkazemi, S., De Meyer, S. and Brown, K. (2017) 'HIV-1 resistance rarely observed in subjects using darunavir once-daily regimens across clinical studies', HIV Clinical Trials, 18(5-6), pp. 196-204.

CAS Number

206361-99-1

Molecular Formula

C27 H37 N3 O7 S

Molecular Weight

547.66

Accurate Mass

547.2352

Smiles

CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]2CO[C@H]3OCC[C@@H]23)S(=O)(=O)c4ccc(N)cc4

InChI

InChI=1S/C27H37N3O7S/c1-18(2)15-30(38(33,34)21-10-8-20(28)9-11-21)16-24(31)23(14-19-6-4-3-5-7-19)29-27(32)37-25-17-36-26-22(25)12-13-35-26/h3-11,18,22-26,31H,12-17,28H2,1-2H3,(H,29,32)/t22-,23-,24+,25-,26+/m0/s1

IUPAC

[(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate

Country of Origin

CANADA

Product Format

Neat

Matrix

-

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